Diffusion coefficient of CO2 in red blood cell

Value 650 µm^2/sec
Organism Human Homo sapiens
Reference Forster RE, Gros G, Lin L, Ono Y, Wunder M. The effect of 4,4'-diisothiocyanato-stilbene-2,2'-disulfonate on CO2 permeability of the red blood cell membrane. Proc Natl Acad Sci U S A. 1998 Dec 22 95(26):15815-20. p.15819 left column 2nd paragraphPubMed ID9861053
Comments "In the present case of C18O16 exchange, the thickness assumed for the cell is the same, D for CO2 is taken as 6.5X10^-6cm^2/sec, and the exchange velocity constant as 44.8sec^-1. This value is calculated from the Mills and Urey relationship (Eq. 1), a CA [carbonic anhydrase] acceleration of 14,000, an uncatalyzed hydration velocity constant of 0.18sec^-1, and a pH of 7.4. The average (intracellular [CO2])/(extracellular [CO2]) is 1, so that the rate of 18O exchange should be the same in cells and in lysate, as Barinov et al. found (2)."
Entered by Uri M
ID 110618