| Range |
≤10 %
|
| Organism |
Human Homo sapiens |
| Reference |
Kondrashov A. Genetics: The rate of human mutation. Nature. 2012 Aug 23 488(7412):467-8. doi: 10.1038/488467a. p.468 left column 3rd paragraphPubMed ID22914161
|
| Primary Source |
1) Kong et al., Rate of de novo mutations and the importance of father's age to disease risk. Nature. 2012 Aug 23 488(7412):471-5. doi: 10.1038/nature11396. (5) Shabalina SA, Ogurtsov AY, Kondrashov VA, Kondrashov AS. Selective constraint in intergenic regions of human and mouse genomes. Trends Genet. 2001 Jul17(7):373-6.PubMed ID22914163, 11418197
|
| Method |
Primary source [1] abstract:"[Researchers] conduct a study of genome-wide mutation rates by sequencing the entire genomes of 78 Icelandic parent-offspring trios at high coverage." |
| Comments |
"In humans, as many as 10% of point mutations are deleterious
[primary source 5], so Kong and colleagues' [primary source 1, 60 new mutations/generation BNID 110293]
findings suggest that an average newborn carries six new deleterious mutations" |
| Entered by |
Uri M |
| ID |
110296 |