| Range |
≈4 unitless
|
| Organism |
Human Homo sapiens |
| Reference |
Callaway E. Fathers bequeath more mutations as they age. Nature. 2012 Aug 23 488(7412):439. doi: 10.1038/488439a. p.439 middle column top paragraphPubMed ID22914142
|
| Primary Source |
Kong et al., Rate of de novo mutations and the importance of father's age to disease risk. Nature. 2012 Aug 23 488(7412):471-5. doi: 10.1038/nature11396.PubMed ID22914163
|
| Method |
"Stefánsson [primary source], whose company maintains
genetic information on most Icelanders,
compared the whole-genome sequences of
78 trios of a mother, father and child. The
team searched for mutations in the child that
were not present in either parent and that must
therefore have arisen spontaneously in the egg,
sperm or embryo. [Primary source] reports the largest
such study of nuclear families so far." |
| Comments |
"Fathers passed on nearly four times as many new mutations as mothers: on average,
55 versus 14." |
| Entered by |
Uri M |
| ID |
110290 |