Number of mutations transmitted to child by fathers of different ages

Range 20 year old father ~25mutations: 40 year old father ~65 mutations mutations
Organism Human Homo sapiens
Reference Kondrashov A. Genetics: The rate of human mutation. Nature. 2012 Aug 23 488(7412):467-8. doi: 10.1038/488467a. p.468 left column top paragraphPubMed ID22914161
Primary Source Kong et al., Rate of de novo mutations and the importance of father's age to disease risk. Nature. 2012 Aug 23 488(7412):471-5. doi: 10.1038/nature11396.PubMed ID22914163
Method Primary source abstract:"[Researchers] conduct a study of genome-wide mutation rates by sequencing the entire genomes of 78 Icelandic parent-offspring trios at high coverage."
Comments "[Primary source researchers' data] reveal that, although a 20-year- old father transmits, on average, approximately 25 mutations to his child, a 40-year-old father transmits around 65. This means that every additional year of paternal age results in an average of two extra mutations in human offspring. By contrast, the authors found that the number of de novo mutations transmitted by the mother is always roughly 15, regardless of her age."
Entered by Uri M
ID 110294