| Range |
20 year old father ~25mutations: 40 year old father ~65 mutations mutations
|
| Organism |
Human Homo sapiens |
| Reference |
Kondrashov A. Genetics: The rate of human mutation. Nature. 2012 Aug 23 488(7412):467-8. doi: 10.1038/488467a. p.468 left column top paragraphPubMed ID22914161
|
| Primary Source |
Kong et al., Rate of de novo mutations and the importance of father's age to disease risk. Nature. 2012 Aug 23 488(7412):471-5. doi: 10.1038/nature11396.PubMed ID22914163
|
| Method |
Primary source abstract:"[Researchers] conduct a study of genome-wide mutation rates by sequencing the entire genomes of 78 Icelandic parent-offspring trios at high coverage." |
| Comments |
"[Primary source researchers' data] reveal that, although a 20-year-
old father transmits, on average, approximately 25 mutations to his child, a 40-year-old father
transmits around 65. This means that every
additional year of paternal age results in an
average of two extra mutations in human
offspring. By contrast, the authors found that
the number of
de novo
mutations transmitted
by the mother is always roughly 15, regardless
of her age." |
| Entered by |
Uri M |
| ID |
110294 |