Number of new mutations per generation

Value 60 new mutations/generation
Organism Human Homo sapiens
Reference Kondrashov A. Genetics: The rate of human mutation. Nature. 2012 Aug 23 488(7412):467-8. doi: 10.1038/488467a. p.467 right columnPubMed ID22914161
Primary Source Kong et al., Rate of de novo mutations and the importance of father's age to disease risk. Nature. 2012 Aug 23 488(7412):471-5. doi: 10.1038/nature11396.PubMed ID22914163
Method Primary source abstract:"[Researchers] conduct a study of genome-wide mutation rates by sequencing the entire genomes of 78 Icelandic parent-offspring trios at high coverage."
Comments "[Primary source researchers] show that a newborn’s genome sequence contains, on average, 60 new small-scale mutations, and that this number depends strongly on the age of the father at the time of conception. [Their] study is by far the largest of its kind yet conducted, involving 78 Icelandic parent–offspring trios."
Entered by Uri M
ID 110293