Lifetime of IL-4 m-RNA in Th2 cells

Range ~90 Minutes
Organism Mouse Mus musculus
Reference Mariani, L., Schulz, E. G., Lexberg, M. H., Helmstetter, C., Radbruch, A., Löhning, M., & Höfer, T. (2010). Short-term memory in gene induction reveals the regulatory principle behind stochastic IL-4 expression. Molecular systems biology, 6(1). p.3 right column bottom paragraphPubMed ID20393579
Method Abstract: "Here, [researchers] study the interleukin-4 gene (il4) in T-helper lymphocytes, combining mathematical modeling with the experimental quantification of expression variability and critical parameters."
Comments P.3 right column bottom paragraph: "From the expression kinetics (Figure 1B), [Researchers] found the lifetimes of IL-4 mRNA and intracellular protein to be ~90min (tR) and ~45min (tP), respectively (Supplementary Figure S3), which is in agreement with an earlier report (Yarovinsky et al, 2006)."
Entered by mar.esther23
ID 110172