Estimated lifetime of the open gate state of IL-4 in Th2 cells

Value 2.9 days
Organism Mouse Mus musculus
Reference Mariani, L., Schulz, E. G., Lexberg, M. H., Helmstetter, C., Radbruch, A., Löhning, M., & Höfer, T. (2010). Short-term memory in gene induction reveals the regulatory principle behind stochastic IL-4 expression. Molecular systems biology, 6(1). p.5 right column top paragraph & bottom paragraphPubMed ID20393579
Method Abstract: "Here, [researchers] study the interleukin-4 gene (il4) in T-helper lymphocytes, combining mathematical modeling with the experimental quantification of expression variability and critical parameters."
Comments P.5 right column bottom paragraph: "The chromatin memory time of the chromatin state found for IL-4 expression, 2.9 days, is one order of magnitude larger than the characteristic time of intracellular IL-4 turnover (~2h Supplementary Mathematical Appendix 1) that provides a basal ‘memory’ for gene expression (Sigal et al, 2006)."
Entered by mar.esther23
ID 110177