| Range |
52.9 corneocytes/mm^2/h
|
| Organism |
Human Homo sapiens |
| Reference |
Hoath SB, Leahy DG. The organization of human epidermis: functional epidermal units and phi proportionality. J Invest Dermatol. 2003 Dec121(6):1440-6. abstract and p.1442 right column bottom paragraphPubMed ID14675195
|
| Method |
"The concept that mammalian epidermis is structurally organized into functional epidermal units has been proposed on the basis of stratum corneum (SC) architecture, proliferation kinetics, melanocyte:keratinocyte ratios (1:36), and, more recently, Langerhans cell: epidermal cell ratios (1:53)." |
| Comments |
"Mathematically, the empirical measures
listed in Table I can be examined under different sets of circumstances
and the results compared with the existing knowledge
base. For example, the assumption of a 14-d turnover time for
the 75,346 cells in the nucleated epidermal compartment yields a
replacement rate of 224 cells per hour. Similar calculations for the
17,778 corneocytes in the stratum corneum yield a replacement
rate of 52.9 cells per hour." |
| Entered by |
Uri M |
| ID |
109886 |