rRNA half-life in vitro in human fibroblast

Range <3 days
Organism Human Homo sapiens
Reference Defoiche J et al., Measurement of ribosomal RNA turnover in vivo by use of deuterium-labeled glucose. Clin Chem. 2009 Oct55(10):1824-33. p.1824 right column top paragraphPubMed ID19696118
Primary Source Gillery P, Georges N, Wegrowski J, Randoux A, Borel JP. Protein synthesis in collagen lattice-cultured fibroblasts is controlled at the ribosomal level. FEBS Lett. 1995 Jan 9 357(3):287-9.PubMed ID7835429
Comments "Ribosomal RNA(rRNA) persists for several days estimates for rRNA half-life in vitro range from <3 days (human fibroblasts) (primary source), through 3.8 days (18S rRNA moiety in H1299 cells) (3), to about 7.5 days (cultured rat fibroblasts) (4 )."
Entered by Uri M
ID 108025