Half-lives of both ribosomal protein and rRNA

Value 5 days
Organism Rat Rattus norvegicus
Reference Hirsch CA, Hiatt HH. Turnover of liver ribosomes in fed and in fasted rats. J Biol Chem. 1966 Dec 25 241(24):5936-40. p.5938 right column bottom paragraphPubMed ID5954370
Method "[Researchers] wished first to determine the kinetics of turnover of liver cytoplasmic ribosomes under conditions approximating a steady state in which synthesis is balanced by catabolism. The method was to label the ribosomal protein and RNA moieties in a series of animals and to measure the specific activities of these components at intervals the rate of decrease indicates the rate of production of unlabeled ribosomes, which in well fed, mature animals also approximates the rate of degradation."
Comments "The half-lives of 5 davs for both ribosomal protein and RNA that [researchers] have measured in the livers of well fed rats agree with reported values for the RNA component (17) and for total rat liver RNA (8)."
Entered by Uri M
ID 110054