18S rRNA moiety half-life in vitro in H1299 (human non-small cell lung carcinoma cell line)

Value 3.8 days
Organism Human Homo sapiens
Reference Defoiche J et al., Measurement of ribosomal RNA turnover in vivo by use of deuterium-labeled glucose. Clin Chem. 2009 Oct55(10):1824-33. p.1824 doi: 10.1373/clinchem.2008.119446. right column top paragraphPubMed ID19696118
Primary Source Yi X, Tesmer VM, Savre-Train I, Shay JW, Wright WE. Both transcriptional and posttranscriptional mechanisms regulate human telomerase template RNA levels. Mol Cell Biol. 1999 Jun19(6):3989-97.PubMed ID10330139
Comments "Ribosomal RNA (rRNA) persists for several days estimates for rRNA half-life in vitro range from <3 days (human fibroblasts) (ref 2), through 3.8 days (18S rRNA moiety in H1299 cells) (primary source), to about 7.5 days (cultured rat fibroblasts) (ref 4)."
Entered by Uri M
ID 108023