Cultured rat fibroblast rRNA half-life in vitro

Range ~7.5 days
Organism Rat Rattus norvegicus
Reference Defoiche J et al., Measurement of ribosomal RNA turnover in vivo by use of deuterium-labeled glucose. Clin Chem. 2009 Oct55(10):1824-33. doi: 10.1373/clinchem.2008.119446. p.1824 right column top paragraphPubMed ID19696118
Primary Source Halle JP, Müller S, Simm A, Adam G. Copy number, epigenetic state and expression of the rRNA genes in young and senescent rat embryo fibroblasts. Eur J Cell Biol. 1997 Nov74(3):281-8.PubMed ID9402476
Comments "Ribosomal RNA(rRNA) persists for several days estimates for rRNA half-life in vitro range from <3 days (human fibroblasts) (ref 2), through 3.8 days (18S rRNA moiety in H1299 cells) (BNID 108023), to about 7.5 days (cultured rat fibroblasts) (primary source)."
Entered by Uri M
ID 108024