Number of proteins in NPC (Nuclear Pore Complex)

Range ≥456 proteins
Organism Budding yeast Saccharomyces cerevisiae
Reference Alber F et al., Determining the architectures of macromolecular assemblies. Nature. 2007 Nov 29 450(7170):683-94. p.683 left column 2nd paragraphPubMed ID18046405
Primary Source Rout MP, Aitchison JD, Suprapto A, Hjertaas K, Zhao Y, Chait BT. The yeast nuclear pore complex: composition, architecture, and transport mechanism. J Cell Biol. 2000 Feb 21 148(4):635-51PubMed ID10684247
Comments Yeast NPCs are ~50 MDa structures built of multiple copies of some 30 different proteins (nucleoporins), totalling at least 456 protein molecules
Entered by Uri M
ID 107690