Recycling time of synaptic vesicles

Range 1 to 2 Sec
Organism Rat Rattus norvegicus
Reference Scimemi A, Beato M. Determining the neurotransmitter concentration profile at active synapses. Mol Neurobiol. 2009 Dec40(3):289-306. p.292 right column bottom paragraphPubMed ID19844813
Primary Source Aravanis AM, Pyle JL, Tsien RW. Single synaptic vesicles fusing transiently and successively without loss of identity. Nature. 2003 Jun 5 423(6940):643-7.PubMed ID12789339
Method At hippocampal synapses, partial fusion (although not necessarily partial neurotransmitter discharge) initially emerged as the predominant mode of neurotransmitter release. This feature has been proposed to speed the recycling time of synaptic vesicles substantially, to 1-2 s (primary source).
Entered by Uri M
ID 107303