| Value |
200000
Molecules/cell
Range: Table - link Molecules/cell
|
| Organism |
Human Homo sapiens |
| Reference |
Mark D. Biggin, Animal Transcription Networks as Highly Connected, Quantitative Continua, Developmental cell Volume 21, Issue 4, 18 October 2011, Pages 611-626 DOI 10.1016/j.devcel.2011.09.008 p.617 table 1PubMed ID22014521
|
| Primary Source |
Nordeen SK, Kühnel B, Lawler-Heavner J, Barber DA, Edwards DP. A quantitative comparison of dual control of a hormone response element by progestins and glucocorticoids in the same cell line. Mol Endocrinol. 1989 Aug3(8):1270-8.PubMed ID2550815
|
| Method |
(Primary source abstract:) "To quantitatively study dual responsiveness of the mouse mammary tumor virus (MMTV) promoter to progestins and glucocorticoids, [researchers] have stably transfected T47D cells with a glucocorticoid receptor (GR) expression vector." |
| Comments |
"A survey of all credible published estimates that [Biggin] could find for four well studied species suggests that most animal transcription factors are expressed at 10,000–300,000 molecules per nucleus (Table 1). These estimates are further supported by [his] own experience and that of many other biochemists who have purified additional endogenous transcription factors with similar yields to the proteins in Table 1." "The data in Table 1 may be biased toward easily studied proteins, so the identification of transcription factors expressed at lower levels may identify better candidates for Coselective DNA Binding-based regulation." |
| Entered by |
Uri M |
| ID |
106911 |