| Value |
0.025
% per chromosome per mitosis
|
| Organism |
Human Homo sapiens |
| Reference |
Thompson and Compton, Examining the link between chromosomal instability and aneuploidy in human cells. J Cell Biol. 2008 Feb 25 180(4):665-72 p.669 left columnPubMed ID18283116
|
| Method |
Abstract: "In this study, [investigators] use live cell imaging and clonal cell analyses to evaluate the fidelity of chromosome segregation in chromosomally stable and unstable human cells." |
| Comments |
P.668 right column: "Nevertheless, the rate of chromosome missegregation in untreated RPE-1 and HCT116 cells is ∼0.025% per chromosome and increases to 0.6–0.8% per chromosome upon the induction of merotely through mitotic recovery from either monastrol or nocodazole treatment (Fig. 3 C). These basal and induced rates of chromosome missegregation are similar to those previously measured in primary human fibroblasts (Cimini et al., 1999)." |
| Entered by |
Paul Jorgensen |
| ID |
105283 |