Rate of gain or loss of chromosome in colorectal cancer cell

Value >=1 % per chromosome per generation
Organism Human Homo sapiens
Reference Lengauer C, Kinzler KW, Vogelstein B. Genetic instability in colorectal cancers. Nature. 1997 Apr 10 386(6625):623-7 p.624 left column top paragraphPubMed ID9121588
Method Clones of several cell lines and fusions were expanded through 25 generations before interphase FISH analysis using chromosome-specific centromeric probes.
Comments P.623 right column bottom paragraph: link . Corrected for the number of chromosomes per cell and assuming that CIN (chromosomal instability) affects all chromosomes equally, this translated into a gain or loss of a chromosome in at least one of every five cell divisions.
Entered by Uri M
ID 105319