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macropinocytosis response time of dendritic cell to tumor necrosis factor

Range	24-48 hours
Organism	Human Homo sapiens
Reference	Sallusto F, Cella M, Danieli C, Lanzavecchia A. Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products. J Exp Med. 1995 Aug 1182(2):pp. 399PubMed ID7629501
Method	DCs generated in culture with GM-CSF and IL-4 have been used as a model of immature DCs to identify the signals that may induce their maturation.
Comments	DCs respond to tumor necrosis factor alpha, CD40 ligand, IL-1, and lipopolysaccharide with a coordinate series of changes that include downregulation of macropinocytosis and Fc receptors, disappearance of the class II compartment, and upregulation of adhesion and costimulatory molecules. These changes occur within 1-2 d and are irreversible, since neither pinocytosis nor the class II compartment are recovered when the maturation-inducing stimulus is removed.
Entered by	Uri M
ID	102638