Size of macropinocytosis vesicles

Range 0.3-5 µm
Organism Human Homo sapiens
Reference Sallusto F, Cella M, Danieli C, Lanzavecchia A. Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products. J Exp Med. 1995 Aug 1 182(2):pp. 389PubMed ID7629501
Comments Antigens that fail to bind to cell surface receptors can still be taken up by fluid phase pinocytosis and presented by APCs, but with a much lower efficiency Fluid phase uptake can occur via distinct mechanisms (a) micropinocytosis, i.e., uptake of small vesicles via clathrin-coated pits and (b) macropinocytosis,i.e., uptake of large vesicles (0.5-3 µm) mediated by membrane ruffling driven by the actin cytoskeleton.
Entered by Uri M
ID 102637