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Fraction of cancers with somatic activating mutations in ras

Value	<=30 %
Organism	Human Homo sapiens
Reference	Oliveira JB, Bidère N, Niemela JE, Zheng L, Sakai K, Nix CP, Danner RL, Barb J, Munson PJ, Puck JM, Dale J, Straus SE, Fleisher TA, Lenardo MJ. NRAS mutation causes a human autoimmune lymphoproliferative syndrome. Proc Natl Acad Sci U S A. 2007 May 22 104(21):8953. Epub 2007 May 16.PubMed ID17517660
Primary Source	Barbacid M. ras genes. Annu Rev Biochem. 1987 56:779-827PubMed ID3304147
Comments	The RAS genes (NRAS, KRAS, and HRAS) encode 21-kDa proteins that are members of the superfamily of small GTP-binding proteins, which have diverse intracellular signaling functions including control of cell proliferation, growth, and apoptosis.
Entered by	Uri M
ID	102289