Fraction of mutations in human cancers that DNA replication errors (R) are responsible for

Range two thirds
Organism Human Homo sapiens
Reference Tomasetti C, Li L, Vogelstein B. Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention. Science. 2017 Mar 24 355(6331):1330-1334. doi: 10.1126/science.aaf9011 abstractPubMed ID28336671
Method Abstract: "[Investigators] studied the relationship between the number of normal stem cell divisions and the risk of 17 cancer types in 69 countries throughout the world."
Comments Abstract: "The major role of R [DNA replication errors] mutations in cancer etiology was supported by an independent approach, based solely on cancer genome sequencing and epidemiological data, which suggested that R mutations are responsible for two-thirds of the mutations in human cancers."
Entered by Uri M
ID 115304