Fraction of variance in protein fitness that can be explained by thermostability

Value 18 %
Organism Unspecified
Reference Firnberg E, Labonte JW, Gray JJ, Ostermeier M: A Comprehensive, High-Resolution Map of a Gene's Fitness Landscape. Mol Biol Evol 2014. p.8 right column top paragraphPubMed ID24567513
Primary Source Dehouck Y, Kwasigroch JM, Gilis D, Rooman M. 2011. PoPMuSiC 2.1: a web server for the estimation of protein stability changes upon mutation and sequence optimality. BMC Bioinformatics 12: 151. doi: 10.1186/1471-2105-12-151PubMed ID21569468
Method "Predictions of ??G (?Gwild-type–?Gmutant) using PoPMuSiC (primary source), a more empirical approach than Rosetta [Das and Baker 2008 PMID 18410248, Chaudhury et al. 2010 PMID 20061306] to predicting changes in protein stability, produced similar results and indicated that 18% of the variance in protein fitness can be explained by thermostability (supplementary fig. S12B, Supplementary Material online)."
Comments "The larger a mutation’s deleterious effect on fitness, the higher the probability that the mutation produced a very large predicted energy score (supplementary fig. S12A, Supplementary Material online)."
Entered by Uri M
ID 110453