| Comments |
"The essential features of McLaughlin’s model are found prominently in the regulation of Ste5's association with the plasma membrane. For Ste5, the role of myristoylation is played by the weak protein-protein interaction with the receptor-activated Gß? dimer. The multisite phosphorylation of Ste5 first weakens the association of Ste5 with the membrane and then ultimately reverses it. If the McLaughlin data apply, each Ste5 phosphorylation decreases the binding energy by (probably) about 1.4 kcal/mol." See BNID 105721 |