Abstract
Cyclin-dependent kinase activation can prevent yeast cells from responding to mating pheromone. Strickfaden et al. (2007) now show that this block arises from the multisite phosphorylation of Ste5. This provides a beautiful example of how phosphorylation can produce decisive changes in protein function through bulk electrostatics, without the necessity of intricate conformational changes.
MeSH terms
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Adaptor Proteins, Signal Transducing / chemistry
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Adaptor Proteins, Signal Transducing / metabolism*
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Cyclin-Dependent Kinases / metabolism*
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Cyclins / metabolism*
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Pheromones / metabolism
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Phosphorylation
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Saccharomyces cerevisiae / cytology
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Saccharomyces cerevisiae / metabolism*
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Saccharomyces cerevisiae Proteins / chemistry
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Saccharomyces cerevisiae Proteins / metabolism*
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Static Electricity
Substances
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Adaptor Proteins, Signal Transducing
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Cyclins
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Pheromones
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STE5 protein, S cerevisiae
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Saccharomyces cerevisiae Proteins
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Cyclin-Dependent Kinases