Percentage of total glucose metabolism devoted to energy production (as opposed to generating building blocks) in a cancer cell line

Value >= % Range: >90 %
Organism Mammalian tissue culture cell
Reference DeBerardinis RJ et al., Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc Natl Acad Sci U S A. 2007 Dec 4 104(49):19345-50 p.19349 right column 3rd paragraphPubMed ID18032601
Method Abstract: " Here, [investigators] used 13C NMR spectroscopy to examine the metabolism of glioblastoma cells exhibiting aerobic glycolysis."
Comments p.19349 right column 3rd paragraph: "Like many cancer cell lines, these cells exhibited a high rate of glucose consumption and anaerobic metabolism of pyruvate. By summing the production of lactate and alanine, [investigators] accounted for >90% of total glucose metabolism. Therefore, all remaining glucose-dependent activities (glycosylation, fatty acid synthesis, glycerogenesis, nucleotide biosynthesis, pyruvate oxidation, etc.) accounted for <10% of total glucose utilization."
Entered by Paul Jorgensen
ID 100789