Fraction of neurons in brain in which 70% of the genes are expressed

Range <20 % of cells
Organism Mouse Mus musculus
Reference O'Rourke NA, Weiler NC, Micheva KD, Smith SJ. Deep molecular diversity of mammalian synapses: why it matters and how to measure it. Nat Rev Neurosci. 2012 May 10 13(6):365-79. doi: 10.1038/nrn3170. p.367 left column bottom paragraphPubMed ID22573027
Primary Source Lein, E. S. et al. Genome-wide atlas of gene expression in the adult mouse brain. Nature 445, 168–176 (2007).PubMed ID17151600
Comments p.367 left column bottom paragraph: "Multiple lines of evidence from genomic, immuno-histochemical and physiological studies further point to the potential for vast diversity and its significant implications. It is now well known that within the brain, multiple isoforms of synaptic proteins are expressed differentially between different brain regions and neural cell types [ref 13, primary source]. For example, the Allen Brain project used in situ hybridization to localize 20,000 different genes at the level of single neurons in the mouse brain [primary source]. The analysis revealed that 70% of the genes were expressed in less than 20% of the cells, implying a high degree of molecular variability between cell types."
Entered by Uri M
ID 112020