Typical ratio of NAD+ to NADH in mitochondrial matrix

Value 10 Unitless Range: Table - link Unitless
Organism Unspecified
Reference Nicholls & Ferguson, Bioenergetics 3, Academic press 2002, p. 43 table 3.2
Comments "The standard redox potential at a pH other than zero is more negative than E°, the difference being 2.3RT/F(m/n) mV per pH unit. This corresponds to -60mV/pH when m=n and -30mV/pH when m=1 and n=2 (Table 3.2). Note that the potentials are still calculated relative to the standard hydrogen electrode at pH=0." "In the case of the mitochondrion, Eh,7 for the NADH/NAD+ couple is about -280mV and Eh,7 for the O2/H20 couple is +780mV (note these values differ slightly from the mid-point potentials shown in Table 3.2 because the NADH/NAD+ ratio in the matrix is only about 0.1 and because oxygen comprises only 20% of air)." Not completly certain that in the matrix. Affects the mid point redox potential
Entered by Ron Milo - Admin
ID 100779