Average and median half life of protein

Range ≈43 min
Organism Budding yeast Saccharomyces cerevisiae
Reference Belle A, Tanay A, Bitincka L, Shamir R, O'Shea EK. Quantification of protein half-lives in the budding yeast proteome. Proc Natl Acad Sci U S A. 2006 Aug 29 103(35):13004-9 p.13004 right column 4th paragraphPubMed ID16916930
Method Abstract: "Using an epitope-tagged strain collection, [researchers] measured the half-life of >3,750 proteins in the yeast proteome after inhibition of translation."
Comments P.13004 right column 4th paragraph: "[Researchers] measured the half-life of 3,751 proteins and found the distribution of half-lives to be approximately log-normal, with a mean and median half-life of ˜43 min (Fig. 1C). The distribution deviates from log-normal in that [they] observe an unexpected number of very unstable proteins (161 proteins with a half-life of <4 min), consistent with the idea that degradation may determine the abundance of these proteins." See BNID 102058, 104386
Entered by Uri M
ID 104151