GSH [glutathione] concentration

Range 1 - 10 mM
Organism Generic
Reference Baudouin-Cornu P, Lagniel G, Kumar C, Huang ME, Labarre J. Glutathione degradation is a key determinant of glutathione homeostasis. J Biol Chem. 2012 Feb 10 287(7):4552-61. doi: 10.1074/jbc.M111.315705 p.4552 left column bottom paragraphPubMed ID22170048
Method Abstract: "Combining mathematical models and (35)S labeling, [investigators] analyzed Saccharomyces cerevisiae sulfur metabolism. This led [them] to the observation that GSH [glutathione] recycling is markedly faster than previously estimated. [They] set up additional in vivo assays and concluded that under standard conditions, GSH half-life is around 90 min."
Comments P.4552 left column bottom paragraph: "Glutathione (GSH) is a very important tripeptide present in quantity ranging from 1 to 10 mM in all cellular types. GSH is involved in a multitude of cellular processes, including detoxification of xenobiotics, antioxidant defense, proliferation, and apoptosis. Deficiency in GSH contributes to oxidative stress, which plays a key role in aging and in the development of many human diseases, including neurodegenerative diseases, liver diseases, diabetes, cystic fibrosis, AIDS, heart attack, and cancers. GSH is synthesized in the cytosol by two enzymes, the γ-glutamylcysteine synthetase (γ-GCS),[ref 3] considered as the rate-limiting enzyme of the pathway, and the glutathione synthetase (see Fig. 1)." See BNID 113869
Entered by Uri M
ID 113865