Experimental conductances for 0.1 or 1.0M GuanHCl, NaCl and KCl in various bilayers at 298K

Range Table - link
Organism Generic
Reference Vorobyov I. et al., Ion-induced defect permeation of lipid membranes. Biophys J. 2014 Feb 4 106(3):586-97. doi: 10.1016/j.bpj.2013.12.027. p.592 table 2PubMed ID24507599
Method Abstract: "[Investigators] have explored the mechanisms of uncatalyzed membrane ion permeation using atomistic simulations and electrophysiological recordings." P.586 left column top paragraph: "Here [investigators] have used molecular dynamics (MD) simulations and electrophysiological measurements to better understand and quantify charge-membrane transport processes."
Comments P.591 right column 2nd paragraph: "Table 2 summarizes [investigators'] experimental results for membrane conductances in different bilayers. For the KCl, NaCl, and GuanHCl salts tested, the conductances vary only within an order of magnitude, suggesting that the permeation process is nonselective. The conductances are similar in bilayers formed by ether or ester phospholipids, which have dipole potentials differing by 100–250 mV (ref 28), corresponding to an energy difference of 2.4–6.0 kcal/mol. This suggests that the permeating ions sense little of the membrane dipole potential, consistent with an ion-induced-defect permeation mechanism." See notes beneath table DPhPC=[1,2-diphytanoyl-sn-glycero-3-phosphocholine], GuanH+=[arginine side chain analog guanidinium]
Entered by Uri M
ID 112545