Rate of action potentials following stimulation

Value 10 Hz
Organism Rat Rattus norvegicus
Reference Rangaraju V, Calloway N, Ryan TA. Activity-driven local ATP synthesis is required for synaptic function. Cell. 2014 Feb 13 156(4):825-35. doi: 10.1016/j.cell.2013.12.042. p.828 right columnPubMed ID24529383
Comments "Although the above experiments clearly demonstrate that the firing state of neurons has a large influence on ATP consumption, the simple absence or presence of TTX [Tetrodotoxin] is a relatively blunt tool for examining the impact of activity. [Researchers] therefore examined ATP levels in synapses during defined bursts of electrical activity. [They] monitored Syn-ATP [a quantitative genetically encoded optical reporter of presynaptic ATP] over a 10 min period during which neurons were stimulated with a 60 s burst of 10 Hz firing (in the absence of TTX)."
Entered by Uri M
ID 111087