Spontaneous firing rates of cerebellar Purkinje neurons

Range ~50 Hz
Organism Rat Rattus norvegicus
Reference Kress GJ, Mennerick S. Action potential initiation and propagation: upstream influences on neurotransmission. Neuroscience. 2009 Jan 12 158(1):211-22. doi: 10.1016/j.neuroscience.2008.03.021. p.213 left column 2nd paragraphPubMed ID18472347
Primary Source Hausser M, Roth A (1997) Dendritic and somatic glutamate receptor channels in rat cerebellar Purkinje cells. J Physiol (Lond) 501: 77–95. & Smith SL, Otis TS (2003) Persistent changes in spontaneous firing of Purkinje neurons triggered by the nitric oxide signaling cascade. J Neurosci 23:367–372.PubMed ID9174996, 12533595
Comments "Many neurons capable of firing sustained, high-frequency trains (fast-spiking neurons) possess substantial resurgent sodium currents (Raman and Bean, 1997, 1999). This includes cerebellar Purkinje neurons, with spontaneous firing rates of ~50 Hz (primary sources). Resurgent sodium currents are voltage-dependent and tetrodotoxin sensitive. Channels open briefly and then become blocked by a voltagedependent, open-channel blocker that unbinds rapidly at negative potentials (Raman and Bean, 2001)."
Entered by Uri M
ID 111175