Permeability of human red cell membranes to D-glucose

Range 10^-5 to 4X10^-4 cm/sec
Organism Human Homo sapiens
Reference Jung, C. Y. 1971. Permeability of bimolecular membranes made from lipid extracts of human red cell ghosts to sugar. J. Membrane Biol. 5: 200-214. p.210 2nd paragraphPubMed ID24173101
Comments "On intact human red cell membranes, the permeability [see [1] below], at the infinitesimal concentration, to D-glucose of 10^-5 to 4x10^-4 cm/sec has been estimated on the basis of kinetic analysis of the transport affinity (Km) and the maximum rate (Vmax) (LeFevre & McGinniss, 1960 Miller, 1968 Jung, 1971)...[1]For sugars which are transported by a saturable path, a true permeability P cannot be calculated. Permeability calculated at an infinitesimal concentration of the sugars, where no saturation is effective, however, would provide a unique measure of relative permeation by different permeants. This permeability at an infinitesimal concentration of the permeant is obtainable by taking the first derivative of the classical Michaelis- Menten expression of the carrier-mediated flux (Wilbrandt & Rosenberg, 1961) with respect to the permeant concentration, at the condition of zero permeant concentration, (Vmax/Km), then dividing by the total surface area of the cells. The values of 1.55x10^-6cm^2 and 8.7x10-11cm^3 were adopted for the surface area and the volume, respectively, of a single human red cell (Whittam, 1964)."
Entered by Uri M
ID 110804