Percentage of 'long lived' proteins that are degraded per hour

Range 1 to 2 %/hour
Organism Mammals
Reference Goldberg AL. Protein degradation and protection against misfolded or damaged proteins. Nature. 2003 Dec 18 426(6968):895-9. p.897 left column top paragraphPubMed ID14685250
Primary Source Gronostajski RM, Pardee AB, Goldberg AL. The ATP dependence of the degradation of short- and long-lived proteins in growing fibroblasts. J Biol Chem. 1985 Mar 25 260(6):3344-9.PubMed ID3972829
Method (Primary source abstract:) By treating CHEF-18 cells with increasing concentrations of dinitrophenol and 2-deoxyglucose, it was possible to reduce their steady-state ATP content by different amounts (up to 98%).
Comments Although many proteins are short-lived, the bulk of cell proteins are ‘long-lived’, and 1–2% of them are degraded per hour in mammals (primary source)
Entered by Uri M
ID 108153