Range 
2025 cal/mol/Å^2

Organism 
Generic 
Reference 
Reynolds JA, Gilbert DB, Tanford C. Empirical Correlation Between Hydrophobic Free Energy and Aqueous Cavity Surface Area. Proc Natl Acad Sci U S A. 1974 Aug71(8):29252927. abstract, p.2925 right column 3rd paragraph & p.2927 left column 5th paragraphPubMed ID16578715

Method 
Calculated from equation [1]: µ°Wµ°HC=RTln[X(HC)/X(W)] where X(HC) and X(W) are the equilibrium concentrations in mole fraction units in hydrocarbon and water, respectively, and µ°HC and µ°W are the corresponding standard chemical potentials. This equation developed into eq. 3 and graph plotted with chemical potential difference (left side of eq.[1]) as ordinate and cavity surface area as abscissa (fig. 2). The slope is 2025 cal/mol/Å^2. Based on empirical data. 
Comments 
"The proportionality constant is 2125
cal/mole per Å^2 for saturated aliphatic hydrocarbons and
=20 cal/mole per Å^2 for aromatic hydrocarbons." 
Entered by 
Ben Marks 
ID 
101826 