| Comments |
"The synthesis of full-length
daughter strands requires approximately 1 hr, and the
entire cycle is completed in approximately 2 hr. This
means that the overall rate of polymerization is only
~270 nucleotides per minute per strand, one of the
slowest in vivo DNA-replication rates reported to date.
In contrast, Escherichia coli DNA is replicated at ~200
times this rate (Kornberg, 1980 and see BNID 102052). It is conceivable that this unimpressive rate of strand elongation is related to the fact that the inner matrix of the mitochondrial organelle is very dehydrated (Hackenbrock, 1968)." For replication rate of 3bp/sec in vitro see BNID 104929, 105371 |