| Comments |
P.18 right column top paragraph: "Besides proteases that play a role in protein import such as Icp55, MPP or Oct1, maintaining mitochondrial homeostasis requires a dedicated protein turnover machinery. This is particularly relevant as the components of the respiratory chain are encoded by both the mitochondrial and the nuclear genome. Imbalanced regulation may result in protein accumulation to avoid wrong complex stoichiometries. Moreover, the production of reactive oxygen species (ROS) renders especially IMM (inner mitochondrial membrane) proteins susceptible to undergo oxidative damage (Baker et al., 2011). Indeed, it is estimated that in logarithmically growing yeast 6–12% of imported mitochondrial proteins are degraded after import (primary source). Consequently, mitochondria possesses their own protein turnover machinery, composed of proteases and chaperones, responsible to maintain homeostasis especially under stress conditions (Baker et al., 2011, Pellegrino et al., 2013)." |