Fraction of genome that comprises protein kinase gene family

Range ~2 %
Organism Eukaryotes
Reference Ubersax JA, Ferrell JE Jr. Mechanisms of specificity in protein phosphorylation. Nat Rev Mol Cell Biol. 2007 Jul8(7):530-41. doi:10.1038/nrm2203 p.520 left column 2nd paragraphPubMed ID17585314
Primary Source [1] G Manning, DB Whyte, R Martinez, T Hunter, S Sudarsanam, The Protein Kinase Complement of the Human Genome Science. 2002 Dec 6 298(5600):1912-34. [3] The mouse kinome: Discovery and comparative genomics of all mouse protein kinases. S Caenepeel, G Charydczak, S Sudarsanam, T Hunter and G Manning (2004). PNAS 101 (32) 11707-11712. [4] Zhu, H. et al. Analysis of yeast protein kinases using protein chips. Nature Genet. 26, 283–289 (2000).PubMed ID12471243, 15289607, 11062466
Comments P.520 left column 2nd paragraph: "Considering their broad importance in signal transduction, it is not surprising that protein kinases are one of the largest families of genes in eukaryotes — making up ~2% of the genome — and have been extensively studied [primary sources]." Primary sources [1], [3] & [4] studied human, mouse & yeast, respectively
Entered by Uri M
ID 112581