||Wagner, A., Energy Constraints on the Evolution of Gene Expression, Mol. Biol. Evol. 22(6):1365–1374. 2005 p.1365 left column top paragraphPubMed ID15758206
||(1) Rubin et al, Comparative genomics of the eukaryotes. Science. 2000 Mar 24 287(5461):2204-15 (2) Conant GC, Wagner A. GenomeHistory: a software tool and its application to fully sequenced genomes. Nucleic Acids Res. 2002 Aug 1 30(15):3378-86PubMed ID10731134, 12140322
||Primary source (2) Researchers present a publicly available software tool (http://www.unm.edu/~compbio/software/GenomeHistory) that identifies all pairs of duplicate genes in a genome and then determines the degree of synonymous and non-synonymous divergence between each duplicate pair. Using this tool, they analyze the relations between (i) gene function and the propensity of a gene to duplicate and (ii) the number of genes in a gene family and the family's rate of sequence evolution.
and 50% of a eukaryotic genome’s gene content consists
of duplicated genes (primary sources)"