Epithelial turnover rate of the healthy esophagus

Range ~11 days
Organism Human Homo sapiens
Reference Tomasetti C, Li L, Vogelstein B. Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention. Science. 2017 Mar 24 355(6331):1330-1334. doi: 10.1126/science.aaf9011 Supplementary Materials p.4 top paragraphPubMed ID28336671
Primary Source [50] Pan Q et al., Identification of lineage-uncommitted, long-lived, label-retaining cells in healthy human esophagus and stomach, and in metaplastic esophagus. Gastroenterology. 2013 Apr144(4):761-70. doi: 10.1053/j.gastro.2012.12.022PubMed ID23266557
Method Primary source abstract: "[Investigators] investigated the existence of uncommitted, slowly cycling cells by tracking 5-iodo-2'-deoxyuridine (IdU) label-retaining cells (LRCs) in normal esophagus, Barrett's esophagus (BE), esophageal dysplasia, adenocarcinoma, and healthy stomach tissues from patients."
Comments Supplementary Materials p.4 top paragraph: "The epithelial turnover rate of the healthy human esophagus is ~11 days (primary source)."
Entered by Uri M
ID 115557