Division rate in prostatic cancer cells

Value 23.1 days
Organism Human Homo sapiens
Reference Tomasetti C, Li L, Vogelstein B. Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention. Science. 2017 Mar 24 355(6331):1330-1334. doi: 10.1126/science.aaf9011 Supplementary Materials p.3 bottom paragraphPubMed ID28336671
Primary Source [48] Rew DA, Wilson GD. Cell production rates in human tissues and tumours and their significance. Part II: clinical data. Eur J Surg Oncol. 2000 Jun26(4):405-17 DOI: 10.1053/ejso.1999.0907PubMed ID10873364
Method Primary source abstract: "This paper reviews the available data for cell production rates of human tissues and tumours, measured in vivo using halogenated pyrimidine labelling and laser cytometry. The technique has now been widely evaluated, and [investigators] draw general inferences from the proliferative data over a broad range of tumour and tissue types."
Comments Supplementary Materials p.3 bottom paragraph: "It has been shown that in human normal epithelium (Nep) of the prostate, 0.8% – 0.86% of cells are Ki67 positive, versus 3.3-5.5% in prostate carcinomas (PCa) (ref 47). Thus, [investigators] estimated that normal prostatic tissue divides at 0.83/4.4=18.9% of that of prostate cancer cells. As the division rate in prostatic cancer cells is every 23.1 days or 365/23.1 =15.8 times a year (primary source), the normal prostate turnover is 15.8×0.189 = 2.986, i.e., 3 times a year."
Entered by Uri M
ID 115556