Peak (gw=gestational weeks) proliferation of neurons in dentate gyrus of hippocampus

Value 14 gestational weeks
Organism Human Homo sapiens
Reference Sorrells SF et al., Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults. Nature. 2018 Mar 15 555(7696):377-381. doi: 10.1038/nature25975 p.377 left column bottom paragraphPubMed ID29513649
Primary Source [15] Yang P et al., Developmental profile of neurogenesis in prenatal human hippocampus: an immunohistochemical study. Int J Dev Neurosci. 2014 Nov38 :1-9. doi: 10.1016/j.ijdevneu.2014.06.015PubMed ID24999120
Method P.377 left column bottom paragraph: "[Investigators] used 59 post-mortem and post-operative samples of the human hippocampus (Supplementary Table 1) to investigate the presence of progenitor cells and young neurons from fetal to adulthood stages." Primary source abstract: "So in the present study, [investigators] aim at immunohistochemically providing more information on neurogenesis in prenatal human hippocampus from 9 weeks to 32 weeks of gestation."
Comments P.377 left column bottom paragraph: "At 14 gestational weeks, at the peak of proliferation in the fetal dentate gyrus (DG)(primary source), many dividing (Ki-67+) neural progenitors (SOX1+ (ref. 16) and SOX2+ (ref. 17)) were observed in the dentate neuroepithelium (dNE, Fig. 1a, Extended Data Fig. 1a–c and Supplementary Video 1)." Primary source abstract: "[Investigators] found that the ki67-positive cells were always detected in hippocampus from 9 weeks to 32 weeks, with a peak at 9 weeks in cornu ammonis (CA)(BNID 117226) or 14 weeks in dentate gyrus (DG)."
Entered by Uri M
ID 117225