Number of neurons per cubic millimeter (mean±SEM) and the percentage of synaptic junctions per layer

Range Table - link
Organism Human Homo sapiens
Reference Alonso-Nanclares L, Gonzalez-Soriano J, Rodriguez JR, DeFelipe J. Gender differences in human cortical synaptic density. Proc Natl Acad Sci U S A. 2008 Sep 23 105(38):14615-9. doi: 10.1073/pnas.0803652105. p.14616 table 1PubMed ID18779570
Method P.14615 right column 3rd paragraph:"Light Microscopy Analysis: [Investigators] analyzed the thickness and neuronal density in layers I, II, IIIA, IIIB, IV, V, and VI of 100-µm Nissl-stained sections from the tissue obtained. No significant differences were found between men and women regarding the neuronal density (Table 1 and Fig. 1A) as previously reported in the temporal neocortex (ref 13)."
Comments P.14615 right column 3rd paragraph:"However, other reports have shown greater neuronal density in the posterior temporal neocortex of women when compared with men (ref 12). The discrepancy between the study of Pakkenberg and Gundersen (ref 13) and [investigators’] present results when compared with those obtained by Witelson et al. (ref 12) may be attributed to the cytoarchitectonic differences of the regions examined. Indeed, [investigators] examined the anterior part of the middle temporal gyrus, corresponding to area 21 of Brodmann [supporting information (SI) Fig. S1] (ref 17), whereas they analyzed the superficial surface of the posterior part of the superior temporal gyrus, also denominated the TA1 area (ref 18) or area 22 by Brodmann (ref 17)."
Entered by Uri M
ID 112050