| Value |
14
gestational weeks
|
| Organism |
Human Homo sapiens |
| Reference |
Sorrells SF et al., Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults. Nature. 2018 Mar 15 555(7696):377-381. doi: 10.1038/nature25975 p.377 left column bottom paragraphPubMed ID29513649
|
| Primary Source |
[15] Yang P et al., Developmental profile of neurogenesis in prenatal human hippocampus: an immunohistochemical study. Int J Dev Neurosci. 2014 Nov38 :1-9. doi: 10.1016/j.ijdevneu.2014.06.015PubMed ID24999120
|
| Method |
P.377 left column bottom paragraph: "[Investigators] used 59 post-mortem and post-operative samples of the human hippocampus (Supplementary Table 1) to investigate the presence of progenitor cells and young neurons from fetal to adulthood stages." Primary source abstract: "So in the present study, [investigators] aim at immunohistochemically providing more information on neurogenesis in prenatal human hippocampus from 9 weeks to 32 weeks of gestation." |
| Comments |
P.377 left column bottom paragraph: "At 14 gestational weeks, at the peak of proliferation in the fetal dentate gyrus (DG)(primary source), many dividing (Ki-67+) neural progenitors (SOX1+ (ref. 16) and SOX2+ (ref. 17)) were observed in the dentate neuroepithelium (dNE, Fig. 1a, Extended Data Fig. 1a–c and Supplementary Video 1)." Primary source abstract: "[Investigators] found that the ki67-positive cells were always detected in hippocampus from 9 weeks to 32 weeks, with a peak at 9 weeks in cornu ammonis (CA)(BNID 117226) or 14 weeks in dentate gyrus (DG)." |
| Entered by |
Uri M |
| ID |
117225 |