| Value |
120
µm/hour
|
| Organism |
in vitro |
| Reference |
Lim DA, Alvarez-Buylla A. The Adult Ventricular-Subventricular Zone (V-SVZ) and Olfactory Bulb (OB) Neurogenesis. Cold Spring Harb Perspect Biol. 2016 May 2 8(5). pii: a018820. doi: 10.1101/cshperspect.a018820 p.14 left column bottom paragraphPubMed ID27048191
|
| Primary Source |
Wichterle H, Garcia-Verdugo JM, Alvarez-Buylla A. Direct evidence for homotypic, glia-independent neuronal migration. Neuron. 1997 May18(5):779-91 DOI: 10.1016/s0896-6273(00)80317-7PubMed ID9182802
|
| Method |
Primary source abstract: "[Investigators] have developed a culture system in which postnatal mouse SVZ neuronal precursors assemble into chains with ultrastructural and immunocytochemical characteristics equivalent to those in vivo but without the astrocytic sheath. Time-lapse videomicrography revealed that individual cells migrate along the chains very rapidly (approximately 122 microm/hr) in both directions." |
| Comments |
P.14 left column bottom paragraph: "After birth in the V-SVZ [Ventricular–Subventricular Zone], type A cells migrate a considerable distance (up to several mm) through a complex network of paths that converge as the RMS [rostral migratory stream] leads neuroblasts into the OB [olfactory bulb]. This journey is not only remarkable for the great distance but also for the highly directed nature of the migration. Type A cells appear to be actively guided rostrally, and very few appear to deviate from the restricted path into the OB. By themselves, type A cells are imbued with an extensive migratory capacity. In vitro, type A cells form chains of themselves and migrate at relatively high speeds of 120 µm/h (primary source)." |
| Entered by |
Uri M |
| ID |
117223 |