Speed of mitochondria transported by kinesin and dynein motors, moving on microtubule tracks

Range ~0.3 – 1 µm/s
Organism Eukaryotes
Reference Harris JJ, Jolivet R, Attwell D. Synaptic energy use and supply. Neuron. 2012 Sep 6 75(5):762-77. doi: 10.1016/j.neuron.2012.08.019. p.770 right column 4th paragraphPubMed ID22958818
Primary Source MacAskill, A.F., Atkin, T.A., and Kittler, J.T. (2010). Mitochondrial trafficking and the provision of energy and calcium buffering at excitatory synapses. Eur. J. Neurosci. 32, 231–240. doi: 10.1111/j.1460-9568.2010.07345.x. & Sheng, Z.-H., and Cai, Q. (2012). Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration. Nat. Rev. Neurosci. 13, 77–93. doi: 10.1038/nrn3156.PubMed ID20946113, 22218207
Comments p.770 right column 4th paragraph:"Mitchondria are formed at the soma. ATP synthesized here would take over 2 min to diffuse to the end of a 200-µm-long dendrite, and ~10 years to diffuse to the end of a 1-m-long axon, preventing rapid adaptation of the ATP supply in response to changing pre- and postsynaptic activity. Instead, therefore, mitochondria are transported long distances around neurons by kinesin and dynein motors, moving on microtubule tracks at ~0.3–1 µm/s. This has been reviewed extensively by [primary sources], who provide more detail on the following points."
Entered by Uri M
ID 111658