| Range |
BBB endothelial cells 1500-2000: other tissues 3-33 Ω.cm^2
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| Organism |
Unspecified |
| Reference |
Stamatovic SM, Keep RF, Andjelkovic AV. Brain endothelial cell-cell junctions: how to "open" the blood brain barrier. Curr Neuropharmacol. 2008 Sep6(3):179-92. doi: 10.2174/157015908785777210 p.179 left column 2nd paragraphPubMed ID19506719
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| Primary Source |
[27] Butt HJ, Downing KH, Hansma PK. Imaging the membrane protein bacteriorhodopsin with the atomic force microscope. Biophys J. 1990 Dec58(6):1473-80 DOI: 10.1016/S0006-3495(90)82492-9 [40] Crone C, Christensen O. Electrical resistance of a capillary endothelium. J Gen Physiol. 1981 Apr77(4):349-71 DOI: 10.1085/jgp.77.4.349PubMed ID2275963, 7241087
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| Method |
Primary source [27] abstract: "The membrane protein bacteriorhodopsin was imaged in buffer solution at room temperature with the atomic force microscope. Three different substrates were used: mica, silanized glass and lipid bilayers." Primay source [40] abstract: "The electrical resistance of consecutive segments of capillaries has been determined by a method in which the microvessels were treated as a leaky, infinite cable. A two-dimensional analytical model to describe the potential field in response to intracapillary current injection was formulated. The model allowed determination of the electrical resistance from four sets of data: the capillary radius, the capillary length constant, the length constant in the mesentery perpendicular to the capillary, and the relative potential drop across the capillary wall." |
| Comments |
P.179 left column 2nd paragraph: "The tight junctions between BBB endothelial cells lead to high endothelial electrical resistance and low paracellular permeability. The electrical resistance is in the range of 1500-2000 Ω.cm^2 (pial vessels) compared to 3-33 Ω.cm^2 in other tissues [primary sources]." |
| Entered by |
Uri M |
| ID |
117112 |