Endothelial cells proliferation rates are higher in tumours relative to normal tissues

Range 20-2,000 fold higher
Organism Unspecified
Reference Raluca BA et al., Endothelial Cell Proliferation and Vascular Endothelial Growth Factor Expression in Primary Colorectal Cancer and Corresponding Liver Metastases. Asian Pac J Cancer Prev. 2015 16(11):4549-53. p.4549 left columnPubMed ID26107202
Primary Source Hobson B, Denekamp J (1984). Endothelial proliferation in tumours and normal tissues: Continuous labelling studies. Br J Cancer, 49, 405-13. AND Zecchin A, Borgers G, Carmeliet P (2015). Endothelial cells and cancer cells: metabolic partners in crime? Curr Opin Hematol, 22, 234-42 doi: 10.1097/MOH.0000000000000138.PubMed ID6201181, 25767953
Method Primary source Hobson et al., 1984 abstract: "The proliferation rate of vascular endothelium has been studied using repeated administrations of tritiated thymidine, given every 8 h for 1 week. Five experimental mouse tumours have been investigated and compared with placenta and with normal tissues...The turnover time of the normal tissue endothelium is estimated to be 20-2000 times longer (47-23,000 days)..."
Comments P.4549 left column: "Normal tissues are characterized by the presence of blood and lymphatic vessels lined by endothelial cells exhibiting a low proliferation rate ranged between 0.1- 3% of all endothelial cells which turnover daily but this percentage decline with age (BNID 112747). Tumor blood vessels have an increased endothelial cells proliferation rate of 20-2000 times higher than in normal tissues (primary sources), representing 0.05% from the total number of human tumor proliferating cells (Kendall et al., 1999)." Primary source Hobson et al. studied mice
Entered by Uri M
ID 112748