Width of periventricular germinal matrix (GM) (in brain) in human fetuses

Range at 23–24 weeks 2.5mm: at 32 weeks 1.4mm: by approximately 36 weeks complete involution mm
Organism Human Homo sapiens
Reference Ballabh P, Braun A, Nedergaard M. The blood-brain barrier: an overview: structure, regulation, and clinical implications. Neurobiol Dis. 2004 Jun16(1):1-13 DOI: 10.1016/j.nbd.2003.12.016 p.6 left column 3rd paragraphPubMed ID15207256
Primary Source Hambleton G, Wigglesworth JS. Origin of intraventricular haemorrhage in the preterm infant. Arch Dis Child. 1976 Sep51(9):651-9 DOI: 10.1136/adc.51.9.651 AND Szymonowicz W, Schafler K, Cussen LJ, Yu VY. Ultrasound and necropsy study of periventricular haemorrhage in preterm infants. Arch Dis Child. 1984 Jul59(7):637-42 DOI: 10.1136/adc.59.7.637PubMed ID999324, 6465933
Method Primary source Hambleton and Wigglesworth abstract: "A technique has been developed for the injection and stereomicroscopic examination of blood vessels in the preterm newborn brain." Primary source Szymonowicz et al., abstract: "The diagnostic accuracy of cerebral ultrasound for periventricular haemorrhage was determined by comparing this with necropsy findings in 30 preterm neonates of 30 weeks' gestation or less and birthweight under 1500 g."
Comments P.6 left column 3rd paragraph: "The wall of the fetal cerebral hemisphere consists the ventricular zone, subventricular zone, intermediate zone, cortical plate, and marginal zone, as described by the Boulder Committee (1970). A localized thickening medial to the basal ganglia in the subventricular zone, which bulges into the lateral ventricle, is referred as the germinal matrix. This periventricular germinal matrix (GM) in human fetuses, located in the region of the thalamostriate groove beneath the ependyma, is densely packed with neuroblasts and glioblasts and is richly supplied with capillaries. It undergoes progressive decrease in size from a width of 2.5 mm at 23–24 weeks to 1.4 mm at 32 weeks and to complete involution by approximately 36 weeks (primary sources)."
Entered by Uri M
ID 117108