||P.477 left column bottom paragraph: "For example human papilloma virus (HPV) is clearly linked to the development of cancer of the cervix.
Elegant molecular mechanisms have demonstrated that the E6 and E7 human papilloma virus proteins bind to and inhibit the activity of the P53 and retinoblastoma (rb) tumour suppressor gene proteins (Dalgleish, 1991). However, only in the past few years is
evidence accumulating that persistent HPV infection is associated with a chronically immune activated state locally in the cervix and, perhaps also systemically. While over 25% of females are infected at ages 19–25, less than 5% remain infected over 35 years of age."