Fraction of females infected with human papilloma virus (HPV)

Range ages 19-25 >25%: over 35 years of age <5% %
Organism Human Homo sapiens
Reference O'Byrne KJ, Dalgleish AG. Chronic immune activation and inflammation as the cause of malignancy. Br J Cancer. 2001 Aug 17 85(4):473-83 DOI: 10.1054/bjoc.2001.1943 p.477 left column bottom paragraphPubMed ID11506482
Comments P.477 left column bottom paragraph: "For example human papilloma virus (HPV) is clearly linked to the development of cancer of the cervix. Elegant molecular mechanisms have demonstrated that the E6 and E7 human papilloma virus proteins bind to and inhibit the activity of the P53 and retinoblastoma (rb) tumour suppressor gene proteins (Dalgleish, 1991). However, only in the past few years is evidence accumulating that persistent HPV infection is associated with a chronically immune activated state locally in the cervix and, perhaps also systemically. While over 25% of females are infected at ages 19–25, less than 5% remain infected over 35 years of age."
Entered by Uri M
ID 117053